Mice were maintained on a high-fructose high-fat diet for 16 weeks to induce a NASH model and received oral administration of the bacterial strains. prausnitzii strains (EB-FPDK3, EB-FPDK9, EB-FPDK11, and EB-FPYYK1) from fecal samples collected from four healthy individuals. prausnitzii could alleviate NASH symptoms, we isolated four F.

Methods: In this study, we conducted 16S rRNA sequencing analyses in patients with NASH and healthy controls. Therefore, we investigated whether a next-generation probiotic candidate, Faecalibacterium prausnitzii, contributed to the mitigation of NASH. Although both traditional and next-generation probiotics have the potential to alleviate various diseases, studies that observe the therapeutic effect of next-generation probiotics on NASH are lacking. A dysbiosis of the gut microbiota has been associated with the pathophysiology of NASH, and probiotics have proven helpful in its treatment and prevention. Introduction: Nonalcoholic steatohepatitis (NASH) is an advanced nonalcoholic fatty liver disease characterized by chronic inflammation and fibrosis.

4Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.3Division of Applied Life Science (BK21 Four), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju-si, Republic of Korea.2R&D Center, Enterobiome Inc., Goyang-si, Republic of Korea.1Research Group of Personalized Diet, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Republic of Korea.†, Eun-Ji Song 1, Dokyung Lee 2, Seo-Yul Jang 2, Hye Rim Byeon 2, Moon-Gi Hong 2, Sang-Nam Lee 2, Hyun-Jin Kim 3, Jae-Gu Seo 2 *, Dae Won Jun 4 * and Young-Do Nam 1 *

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